Desalination of sea water does not have a direct effect on the ocean life.
But applying a filtering of microplastics during or ahead of desalination can help to extract that waste material from the ocean water. Thus, these particles can no longer be accumulated in sea animals.
In addition, denitrification of intensively used agricultural lands helps to improve the quality of groundwater, and hence, reduces the amount of nutrients rinsed into adjacent streams and joint water bodies. Accordingly, ponds and oceans will be affected less by e.g. growth of algae.